The intersection of stress and reward: BNST modulation of aversive and appetitive states
Sarah Ch'ng, Jingjing Fu, Robyn M Brown, Stuart J McDougall, Andrew J Lawrence
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018
The bed nucleus of the stria terminalis (BNST) is widely acknowledged as a brain structure that regulates stress and anxiety states, as well as aversive and appetitive behaviours. The diverse roles of the BNST are afforded by its highly modular organisation, neurochemical heterogeneity, and complex intrinsic and extrinsic circuitry. There has been growing interest in the BNST in relation to psychopathologies such as anxiety and addiction. Although research on the human BNST is still in its infancy, there have been extensive preclinical studies examining the molecular signature and hodology of the BNST and their involvement in stress and reward seeking behaviour. This review examines the neur..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
These studies were supported by a National Health and Medical Research Council (NHMRC) of Australia project grant (1079893) to AJL who is an NHMRC Principal Research Fellow (1116930). RMB is an NHMRC Early Career Research Fellow. SSC is supported by a University of Melbourne International Research Scholarship. JF is supported by the Chinese Scholarship Council. We acknowledge the Victorian State Government Infrastructure Program.