Conference Proceedings
Lynch syndrome-associated breast cancers: Clinicopathological characteristics of a case series from the Colon CFR
Christophe Rosty, Michael Walsh, Margaret Cummings, Daniel Buchanan, Sven Arnold, Diane McKeone, Rhiannon Walters, John Hopper, Mark Jenkins, Amanda Spurdle, Michael McGuckin, Sunil Lakhani, Joanne Young
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2010
Abstract
Abstract Background: Lynch Syndrome is an autosomal dominant condition which predisposes to early-onset cancer of the colorectum, endometrium, and to a lesser extent, stomach, ureter and renal pelvis, ovary, brain and small bowel. It is thought, however, that there is no significant increase in risk of developing breast cancer. The aim of this study was to determine the prevalence and clinicopathological features of breast cancers arising in families with a history of both colorectal and breast malignancy. Design: 107 cases of breast carcinoma (BC) from 90 families were identified from the Australasian Colorectal Cancer Family Registry. Comprehensive cancer hist..
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