Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate

N Pujara; S Jambhrunkar; KY Wong; M McGuckin; A Popat

Journal article

Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate

N Pujara, S Jambhrunkar, KY Wong, M McGuckin, A Popat

Journal of Colloid and Interface Science | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2017

DOI: 10.1016/j.jcis.2016.11.015

Abstract

The polyphenolic compound resveratrol has received significant attention due to its many pharmacological actions such as anti-cancer, anti-inflammatory, antioxidant and antimicrobial activities. However, poor solubility and stability are major impediments for resveratrol's clinical effectiveness. In this work we have encapsulated resveratrol into soy protein isolate nanoparticles using a simple rotary evaporation technique. Resveratrol-loaded nanoparticles were around 100 nm in diameter and negatively charged. Nano-encapsulated resveratrol was found to be in amorphous form and showed more than two times higher solubility with significantly increased dissolution when compared to free resverat..

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University of Melbourne Researchers

Mike McGuckin Author

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Grants

Awarded by Mater Foundation

Funding Acknowledgements

We thank The National Health and Medical Research Council's Project Grant 1107836 and Early Career Fellowship 1071796 to A. Popat and Principal Research Fellowship 1059726 to M. McGuckin, and The University of Queensland and Mater Foundation for financial support. The Translational Research Institute is supported by a grant from the Australian Government. We acknowledge the Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, The University of Queensland. We also would like to thank Dr. Benjamin P Ross for his fruitful suggestions.