Journal article

Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants

Quoc V Tu, Michael A McGuckin, George L Mendz

Journal of Medical Microbiology | MICROBIOLOGY SOC | Published : 2008


Campylobacter jejuni is the main cause of bacterial acute gastroenteritis worldwide. In its colonization of the host intestinal tract, it encounters secreted mucins in the mucus layer and surface mucins in the epithelial cells. Mucins are complex glycoproteins that comprise the major component of mucus and give mucus its viscous consistency. MUC2 is the most abundant secreted mucin in the human intestine; it is a major chemoattractant for C. jejuni, and the bacterium binds to it. There are no studies on the transcriptional response of the bacterium to this mucin. Here, cell-culture techniques and quantitative RT-PCR were used to characterize in vitro the effects of MUC2 on C. jejuni growth a..

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