PREDICTIVE VALUE OF THE COMBINATION OF SERUM MARKERS, CA125, CASA AND TPS IN OVARIAN-CANCER

Abstract

The serum markers CA125, CASA and TPS were compared, with particular reference to the clinical applications of these tumor markers in the management of patients with ovarian cancer (discrimination of benign and malignant disease; indicating prognosis; predicting preclinical recurrence), (i) Using recommended cut-off points, CASA (>/=4 U ml-1 and TPS (>/=80 U l-1 showed similar sensitivities in ovarian carcinoma (56% and 57% respectively), though these were lower than with CA125 (85% >/= 35 U ml-1). The combined use of CA125 with either CASA or TPS at higher cut-off points excluding benign disease (CA125> 345 U ml-1; CASA> 6 U ml-1; TPS> 359 U l-1) improved the discrimination of ovarian cance..