Mucin Dynamics in Intestinal Bacterial Infection
Sara K Linden, Timothy HJ Florin, Michael A McGuckin
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2008
BACKGROUND: Bacterial gastroenteritis causes morbidity and mortality in humans worldwide. Murine Citrobacter rodentium infection is a model for gastroenteritis caused by the human pathogens enteropathogenic Escherichia coli and enterohaemorrhagic E. coli. Mucin glycoproteins are the main component of the first barrier that bacteria encounter in the intestinal tract. METHODOLOGY/PRINCIPAL FINDINGS: Using Immunohistochemistry, we investigated intestinal expression of mucins (Alcian blue/PAS, Muc1, Muc2, Muc4, Muc5AC, Muc13 and Muc3/17) in healthy and C. rodentium infected mice. The majority of the C. rodentium infected mice developed systemic infection and colitis in the mid and distal colon b..View full abstract
Awarded by Swedish Society for Medical Research
Awarded by Australian NHMRC Project
The work was supported by a post doctoral Fellowship from the Swedish Society for Medical Research (to S. Linden), the Swedish Reasearch Council (Vetenskapsradet, to S. Linden) and the Australian NHMRC Project Grant No. 382309.