Journal article

Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases

LM FitzGerald, S Zhao, A Leonardson, MS Geybels, S Kolb, DW Lin, JL Wright, R Eeles, Z Kote-Jarai, K Govindasami, GG Giles, MC Southey, J Schleutker, TL Tammela, C Sipeky, KL Penney, MJ Stampfer, H Gronberg, F Wiklund, P Stattin Show all

PROSTATE CANCER AND PROSTATIC DISEASES | NATURE PUBLISHING GROUP | Published : 2018

Abstract

BACKGROUND: Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further replication evidence is needed. METHODS: Twenty-two previously identified PCSM-associated genetic variants were genotyped in seven PCa cohorts (12,082 patients; 1544 PCa deaths). For each cohort, Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for risk of PCSM associated with each variant. Data were then combined using a meta-analysis approach. RESULTS: Fifteen SNPs were associated with PCSM in at least one of the seven cohorts...

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Grants

Awarded by National Cancer Institute


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE


Funding Acknowledgements

This work was supported by awards from the Movember Foundation (to R.E. and J.L.S.) and grants from the National Cancer Institute (P50 CA097186 and K05 CA175147 to J.L.S.), with additional support from the Fred Hutchinson Cancer Research Center.