Journal article

Bifunctional Succinylated epsilon-Polylysine-Coated Mesoporous Silica Nanoparticles for pH-Responsive and Intracellular Drug Delivery Targeting the Colon

Chau TH Nguyen, Richard I Webb, Lynette K Lamber, Ekaterina Strounina, Edward C Lee, Marie-Odile Parat, Michael A McGuckin, Amirali Popat, Peter J Cabot, Benjamin P Ross



Conventional oral drug formulations for colonic diseases require the administration of high doses of drug to achieve effective drug concentrations at the target site. However, this exposes patients to serious systemic toxicity in order to achieve efficacy. To overcome this problem, an oral drug delivery system was developed by loading a large amount (ca. 34% w/w) of prednisolone into 3-aminopropyl-functionalized mesoporous silica nanoparticles (MCM-NH2) and targeting prednisolone release to the colon by coating the nanoparticle with succinylated ε-polylysine (SPL). We demonstrate for the first time the pH-responsive ability of SPL as a "nanogate" to selectively release prednisolone in the pH..

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Funding Acknowledgements

Chau T.H. Nguyen thanks The University of Queensland (UQ), the UQ School of Pharmacy, and the Vietnamese Government for scholarship funding. The authors acknowledge the facilities, and the scientific and technical assistance, of the Australian Microscopy & Microanalysis Research Facility at the UQ Centre for Microscopy and Microanalysis; the UQ Centre for Advanced Imaging; and the Translational Research Institute. The authors thank Robyn Chapman, Dr. Graeme Auchterlonie, Dr. Sandrine Roy, and Dr. Dalia Khalil for their kind assistance while conducting the research.