Journal article

Antimuscarinic drugs for overactive bladder and their potential effects on cognitive function in older patients.

Gary G Kay, Mohamed B Abou-Donia, William S Messer, Declan G Murphy, Jack W Tsao, Joseph G Ouslander

J Am Geriatr Soc | Published : 2005

Abstract

Antimuscarinic agents are the predominant pharmacological treatment for patients with overactive bladder (OAB). These drugs are thought to act primarily through antagonism at muscarinic M3 receptors located at neuromuscular junctions in the human bladder detrusor muscle. Several of these drugs have been shown to be efficacious in ameliorating the symptoms of OAB in older patients, but most currently available agents lack selectivity for the M3 receptor subtype, and interaction with other muscarinic receptor subtypes throughout the body may adversely affect a variety of physiological functions and result in unwanted side effects, including cognitive dysfunction. With the recent availability o..

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