Journal article

Genetic variation in the serotonin transporter modulates neural system-wide response to fearful faces.

SA Surguladze, A Elkin, C Ecker, S Kalidindi, A Corsico, V Giampietro, N Lawrence, Q Deeley, DGM Murphy, K Kucharska-Pietura, TA Russell, P McGuffin, R Murray, ML Phillips

Genes Brain Behav | Published : 2008


A distributed, serotonergically innervated neural system comprising extrastriate cortex, amygdala and ventral prefrontal cortex is critical for identification of socially relevant emotive stimuli. The extent to which a genetic variation of serotonin transporter gene 5-HTTLPR impacts functional connectivity between the amygdala and the other components of this neural system remains little examined. In our study, neural activity was measured using event-related functional magnetic resonance imaging in 29 right-handed, white Caucasian healthy subjects as they viewed mild or prototypical fearful and neutral facial expressions. 5-HTTLPR genotype was classified as homozygous for the short allele (..

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University of Melbourne Researchers