Journal article

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles

Angela Pizzolla, Thi HO Nguyen, Sneha Sant, Jade Jaffar, Tom Loudovaris, Stuart I Mannering, Paul G Thomas, Glen P Westall, Katherine Kedzierska, Linda M Wakim



The human lung harbors a large population of resident memory T cells (Trm cells). These cells are perfectly positioned to mediate rapid protection against respiratory pathogens such as influenza virus, a highly contagious respiratory pathogen that continues to be a major public health burden. Animal models show that influenza-specific lung CD8+ Trm cells are indispensable for crossprotection against pulmonary infection with different influenza virus strains. However, it is not known whether influenza-specific CD8+ Trm cells present within the human lung have the same critical role in modulating the course of the disease. Here, we showed that human lung contains a population of CD8+ Trm cells..

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Awarded by NHMRC

Awarded by JDRF

Funding Acknowledgements

We thank S. Gras and J. Rossjohn (Monash University) for monomers. This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (to LMW), the CASS Foundation (to LMW), and a NHMRC program grant (1071916 to KK). SS is supported by the Victoria-India Doctoral Scholarship (VIDS) and the Melbourne International Fee Remission Scholarship (MIFRS), and KK is an NHMRC senior research level B fellow. SIM was supported by JDRF (JDRF 17-2011-527), NHMRC (GNT1123586) and the Operational Infrastructure Support Program of the Victorian Government. The Alfred Hospital's Lung Tissue Biobank is supported by the NHMRC Centre of Research Excellence (CRE) in Pulmonary Fibrosis