Journal article
Antimicrobial-resistant klebsiella pneumoniae carriage and infection in specialized geriatric care wards linked to acquisition in the referring hospital
CL Gorrie, M Mirceta, RR Wick, LM Judd, KL Wyres, NR Thomson, RA Strugnell, NF Pratt, JS Garlick, KM Watson, PC Hunter, SA McGloughlin, DW Spelman, AWJ Jenney, KE Holt
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2018
DOI: 10.1093/cid/ciy027
Abstract
Background Klebsiella pneumoniae is a leading cause of extended-spectrum β-lactamase (ESBL)-producing hospital-associated infections, for which elderly patients are at increased risk. Methods We conducted a 1-year prospective cohort study, in which a third of patients admitted to 2 geriatric wards in a specialized hospital were recruited and screened for carriage of K. pneumoniae by microbiological culture. Clinical isolates were monitored via the hospital laboratory. Colonizing and clinical isolates were subjected to whole-genome sequencing and antimicrobial susceptibility testing. Results K. pneumoniae throat carriage prevalence was 4.1%, rectal carriage 10.8%, and ESBL carriage 1.7%, and ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (project 1043822 and fellowship 1061409 to K.E.H.) and the Australian Government Research Training Program (scholarship to C.L.G.).