Diagnosis and significance of pulmonary microvascular disease in diabetes

TJ Roberts; AT Burns; RJ MacIsaac; AI MacIsaac; DL Prior; AL Gerche

Journal article

Diagnosis and significance of pulmonary microvascular disease in diabetes

TJ Roberts, AT Burns, RJ MacIsaac, AI MacIsaac, DL Prior, AL Gerche

Diabetes Care | AMER DIABETES ASSOC | Published : 2018

DOI: 10.2337/DC17-1904

Abstract

OBJECTIVE To determinewhether pulmonary microvascular disease is detectable in subjects with diabetes and associated with diminished exercise capacity using a novel echocardiographicmarker quantifying the pulmonary transit of agitated contrast bubbles (PTAC). RESEARCH DESIGN AND METHODS Sixty participants (40 with diabetes and 20 control subjects) performed cardiopulmonary (maximal oxygen consumption [VO2peak]) and semisupine bicycle echocardiography exercise tests within a 1-week period. Pulmonary microvascular disease was assessed using PTAC (the number of bubbles traversing the pulmonary circulation to reach the left ventricle, categorized as low PTAC or high PTAC). Echocardiographic meas..

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University of Melbourne Researchers

Andrew Burns Author

Richard MacIsaac Author

Andrew MacIsaac Author

David Prior Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was funded by the National Heart Foundation of Australia (Grant-In-Aid G 12M 6396). A.L.G. is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC 1089039) and a Future Leaders Fellowship from the National Heart Foundation of Australia (NHF 100409).