Journal article
Adjunctive glucocorticoid therapy in patients with septic shock
B Venkatesh, S Finfer, J Cohen, D Rajbhandari, Y Arabi, R Bellomo, L Billot, M Correa, P Glass, M Harward, C Joyce, Q Li, C McArthur, A Perner, A Rhodes, K Thompson, S Webb, J Myburgh
New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2018
Abstract
BACKGROUND: Whether hydrocortisone reduces mortality among patients with septic shock is unclear. METHODS: We randomly assigned patients with septic shock who were undergoing mechanical ventilation to receive hydrocortisone (at a dose of 200 mg per day) or placebo for 7 days or until death or discharge from the intensive care unit (ICU), whichever came first. The primary outcome was death from any cause at 90 days. RESULTS: From March 2013 through April 2017, a total of 3800 patients underwent randomization. Status with respect to the primary outcome was ascertained in 3658 patients (1832 of whom had been assigned to the hydrocortisone group and 1826 to the placebo group). At 90 days, 511 pa..
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Awarded by CSL Behring
Funding Acknowledgements
Funded by the National Health and Medical Research Council of Australia and others