Journal article
Epigenetic programming, early life nutrition and the risk of metabolic disease
T Block, A El-Osta
Atherosclerosis | ELSEVIER IRELAND LTD | Published : 2017
Abstract
Time separates the past from the present, during this period memory are formed - written in code and decoded to be read while other memories are erased - but when it comes to the epigenome some memories are harder to forget than others. Recent studies show chemical information is written in the context of the epigenome and codified on histone and non-histone proteins to regulate nuclear processes such as gene transcription. The genome is also subject to modification in the form of 5-methylcytosine, which has been implicated in metabolic memory. In this review, we examine some of the chemical modifications that signal early life events and explore epigenetic changes that underlie the diabetic..
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Awarded by Royal College of Pathologists of Australasia
Funding Acknowledgements
The authors acknowledge grant and fellowship support from the National Health and Medical Research Council (NHMRC, 0526681, 1048377 and 1113188). This work was supported in part by the Royal College of Pathologists of Australasia Pathology for Medical Schools Scholarship. Supported in part by the Victorian Government's Operational Infrastructure Support Program.