Journal article

Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells

Aneta Balcerczyk, Dorota Rybaczek, Martyna Wojtala, Luciano Pirola, Jun Okabe, Assam El-Osta

Biochemical Pharmacology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016

DOI: 10.1016/j.bcp.2016.09.013

University of Melbourne Researchers

Grants

Awarded by National Science Centre - Poland

Funding Acknowledgements

We thank Karolina Fornalczyk for preparative assistance. This study was financed by the National Science Centre - Poland, project grant No. NCN 2012/05/B/NZ2/01663.

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Keywords

Asymmetric Dimethylarginine
Therapy
Mechanisms
Humans
Progression
Xanthenes
Angiogenesis Process
Cancer
Arginine/lysine Histone Methyltransferases
Angiotensin-Ii
Heterochromatin
Science & Technology
Protein
Cell Cycle
Methylation
Neovascularization, Pathologic
Tumor Angiogenesis
Urea
Cell Survival
Angiogenesis Inhibitors
Life Sciences & Biomedicine
Micronuclei, Chromosome-Defective
Pharmacology & Pharmacy
Naphthalenesulfonates
Benzoates
Histone-Lysine N-Methyltransferase
Endothelial Cells
Cell Movement
Protein-Arginine N-Methyltransferases
Disease