Journal article
Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling
SP Gray, E Di Marco, K Kennedy, P Chew, J Okabe, A El-Osta, AC Calkin, EAL Biessen, RM Touyz, ME Cooper, HHHW Schmidt, KAM Jandeleit-Dahm
Arteriosclerosis Thrombosis and Vascular Biology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016
Abstract
Objective-Oxidative stress is considered a hallmark of atherosclerosis. In particular, the superoxide-generating type 1 NADPH oxidase (NOX1) has been shown to be induced and play a pivotal role in early phases of mouse models of atherosclerosis and in the context of diabetes mellitus. Here, we investigated the role of the most abundant type 4 isoform (NOX4) in human and mouse advanced atherosclerosis. Approach and Results-Plaques of patients with cardiovascular events or established diabetes mellitus showed a surprising reduction in expression of the most abundant but hydrogen peroxide (H2O2)-generating type 4 isoform (Nox4), whereas Nox1 mRNA was elevated, when compared with respective cont..
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Awarded by Juvenile Diabetes Research Foundation International
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) project grant of Australia, the Juvenile Diabetes Research Foundation, and the Diabetes Australia Research Trust. K.A.M. Jandeleit-Dahm is supported by a NHMRC Senior Research Fellowship and M.E. Cooper is supported by an NHMRC Senior Principal Research Fellowship. S.P. Gray is supported by the Australian Diabetes Society Skip Martin Early Career Fellowship. E. Di Marco is supported by the National Heart Foundation Postgraduate Scholarship. A.C. Calkin is supported by a National Heart Foundation Future Leader Fellowship. H.H.H.W. Schmidt is supported by the EU (Marie Curie International Reintegration Grant and the ERC Advanced Grant 30983347E RADMED) and a cofounder and minor shareholder of Vasopharm GmbH, Wurzburg, Germany. This study was also supported, in part, by the Victorian Government's Operational Infrastructure Support Program.