Epigenetics and Metabolism
Samuel T Keating, Assam El-Osta
CIRCULATION RESEARCH | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
The molecular signatures of epigenetic regulation and chromatin architectures are fundamental to genetically determined biological processes. Covalent and post-translational chemical modification of the chromatin template can sensitize the genome to changing environmental conditions to establish diverse functional states. Recent interest and research focus surrounds the direct connections between metabolism and chromatin dynamics, which now represents an important conceptual challenge to explain many aspects of metabolic dysfunction. Several components of the epigenetic machinery require intermediates of cellular metabolism for enzymatic function. Furthermore, changes to intracellular metabo..View full abstract
We acknowledge grant and fellowship support from the Juvenile Diabetes Research Foundation International (JDRF), the Diabetes Australia Research Trust (DART), the National Health and Medical Research Council (NHMRC), and the National Heart Foundation of Australia (NHF). A. El-Osta is an NHMRC Senior Research Fellow. Supported in part by the Victorian Government's Operational Infrastructure Support program.