Journal article
Rapid development of non-alcoholic steatohepatitis in Psammomys obesus (Israeli sand rat)
B Spolding, T Connor, C Wittmer, LLF Abreu, A Kaspi, M Ziemann, G Kaur, A Cooper, S Morrison, S Lee, A Sinclair, Y Gibert, JL Trevaskis, JD Roth, A El-Osta, R Standish, K Walder
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2014
Abstract
Background and Aims: A major impediment to establishing new treatments for non-alcoholic steatohepatitis is the lack of suitable animal models that accurately mimic the biochemical and metabolic characteristics of the disease. The aim of this study was to explore a unique polygenic animal model of metabolic disease as a model of non-alcoholic steatohepatitis by determining the effects of 2% dietary cholesterol supplementation on metabolic and liver endpoints in Psammomys obesus (Israeli sand rat). Methods: P. obesus were provided ad libitum access to either a standard rodent diet (20% kcal/fat) or a standard rodent diet supplemented with 2% cholesterol (w/w) for 4 weeks. Histological section..
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Funding Acknowledgements
This research was supported in part by Amylin Pharmaceuticals, Inc., San Diego, USA, and in part by the Deakin University Molecular and Medical Research Strategic Research Centre. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.