Journal article

Genetic Examination of SETD7 and SUV39H1/H2 Methyltransferases and the Risk of Diabetes Complications in Patients With Type 1 Diabetes

Anna Syreeni, Assam El-Osta, Carol Forsblom, Niina Sandholm, Maikki Parkkonen, Lise Tarnow, Hans-Henrik Parving, Amy J McKnight, Alexander P Maxwell, Mark E Cooper, Per-Henrik Groop



OBJECTIVE: Hyperglycemia plays a pivotal role in the development and progression of vascular complications, which are the major sources of morbidity and mortality in diabetes. Furthermore, these vascular complications often persist and progress despite improved glucose control, possibly as a result of prior episodes of hyperglycemia. Epigenetic modifications mediated by histone methyltransferases are associated with gene-activating events that promote enhanced expression of key proinflammatory molecules implicated in vascular injury. In this study, we investigated genetic polymorphisms of the SETD7, SUV39H1, and SUV39H2 methyltransferases as predictors of risk for micro- and macrovascular co..

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University of Melbourne Researchers


Awarded by Public Health Agency

Funding Acknowledgements

The study in Finland was supported by grants from the Folkhalsan Research Foundation, Samfundet Folkhalsan, and the Wilhelm och Else Stockmann Foundation. The Warren 3/GoKinD U.K. Study Group was jointly funded by Diabetes UK and the Juvenile Diabetes Research Foundation and includes the following individuals: Belfast: Professor A.P. Maxwell, Dr. A.J. McKnight, and Dr. D.A. Savage; Edinburgh: Dr. J. Walker; London: Dr. S. Thomas and Professor G.C. Viberti; Manchester: Professor A.J.M. Boulton; Newcastle: Professor S. Marshall; Plymouth: Professor A.G. Demaine and Dr. B.A. Millward; and Swansea: Professor S.C. Bain.