Journal article

A randomized study of intermittent chemotherapy with or without BCG inoculation in maintenance therapy of childhood ALL.

H Ekert, KD Waters, RN Matthews, GP Tauro, MS Rice, R Seshadri, DC Mauger, JR Tiernan, WR McWhirter, P O'Regan, TE Olsen, JD Mathews

Med Pediatr Oncol | Published : 1980

Abstract

One hundred ninety‐six children with acute lymphocytic leukemia were entered into a randomized study of maintenance chemotherapy with either intermittent chemotherapy and immunotherapy with bacillus Calmette‐Guerin (BCG) or only intermittent chemotherapy. On admission to the study, patients were stratified into three prognostic categories on the basis of clinical and laboratory features at presentation. Patients considered to have a favorable prognosis (PF) were induced with vincristine and prednisone; those with an unfavorable prognosis (PU) received combination chemotherapy consisting of either Ara‐C, cyclophosphamide and asparaginase, or vincristine, prednisolone, and daunomycin followed ..

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