Journal article

Genetic and environmental risk factors for chronic kidney disease

Gregorio T Obrador, Ulla T Schultheiss, Matthias Kretzler, Robyn G Langham, Masaomi Nangaku, Roberto Pecoits-Filho, Carol Pollock, Jerome Rossert, Ricardo Correa-Rotter, Peter Stenvinkel, Robert Walker, Chih-Wei Yang, Caroline S Fox, Anna Koettgen



In order to change the current state of chronic kidney disease knowledge and therapeutics, a fundamental improvement in the understanding of genetic and environmental causes of chronic kidney disease is essential. This article first provides an overview of the existing knowledge gaps in our understanding of the genetic and environmental causes of chronic kidney disease, as well as their interactions. The second part of the article formulates goals that should be achieved in order to close these gaps, along with suggested timelines and stakeholders that are to be involved. A better understanding of genetic and environmental factors and their interactions that influence kidney function in heal..

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Awarded by German Research Foundation

Awarded by Japanese Ministry of Health and Labor

Awarded by Else Kroner-Fresenius-Stiftung, Bad Homburg, Germany

Funding Acknowledgements

[ "The manuscript emerged as an individual product of the Global Kidney Health Summit held in Vancouver, Canada in July 2016. Support of the summit was made possible through unrestricted grants from various organizations in addition to the International Society of Nephrology. These include (in alphabetical order): AbbVie Inc., Akebia Therapeutics Inc., Amgen, AstraZeneca LP, Boehringer Ingelheim-Lilly, Danone Nutricia Research, Janssen Canada, Merck Global, and Regulus Therapeutics Inc.", "The work of AK was supported by the CRC 1140 Initiative and by a Heisenberg Professorship (KO 3598/3-1) of the German Research Foundation.", "The work of MN was partly supported by a grant from the Japanese Ministry of Health and Labor (H28-Menneki-Shitei-001). UTS was funded by a grant from the Else Kroner-Fresenius-Stiftung (2013_Kolleg.03), Bad Homburg, Germany." ]