Insulin resistance in peripheral tissues after a burn injury

Abstract

The glucose uptake of a perfused, skin-covered preparation of muscle taken from the rat was altered by prior burn injury to the animal. Animals receiving an 8% deep bum to the back 24 hours prior to testing had a glucose uptake (5.9 ± 0.85 μM/100 gm/min) which was depressed compared with control nonburned preparations (8:4 ± 0.34 μM/100 gm/min) (P < 0.025) at low insulin concentration (35 μU/ml). Higher insulin concentrations (160 μU/ml and 16 mU/ml) produced significant increases in the glucose uptake of both the burned and control animals. At the highest insulin level (16 mU/ml), there was no significant difference between burned and control animals. Preparations from animals burned five d..