Journal article

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Winnie L Kan, Emma F Barry, Mara Dottore, Karen S Cheung Tung Shing, Craig J Morton, Urmi Dhagat, Matthew P Hardy, Nicholas J Wilson, Matthew T Downton, Christine Schieber, Timothy P Hughes, Angel F Lopez, Michael W Parker



Awarded by Victorian Life Sciences Computation Initiative (VLSCI)

Funding Acknowledgements

This research was partly undertaken on the MX2 beamline at the Australian Synchrotron, Victoria, Australia and we thank the beamline staff for their assistance. We thank Anna Sapa for technical assistance, Denis Tvorogov for the HEK293-T cells expressing beta c, Hayley Ramshaw for the TF-1Hi cell line, Paul Ekert (Murdoch Children's Research Institute) for the HoxA9 expression construct, Tony Cambareri for the 1B5 hybridoma and Joanna Woodcock for helpful discussions. We acknowledge the use of the CSIRO Collaborative Crystallisation Centre (C3), Melbourne, Australia for our initial crystallisation studies, and the SA Pathology Detmold Family Cytometry Centre for use of flow cytometry facilities. This research was supported by a Victorian Life Sciences Computation Initiative (VLSCI) grant number RA0002 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia. This work was supported by grants from the National Health and Medical Research Council of Australia (NHMRC) to T.R.H., U.D., M.W.P. and A.F.L., Cure Cancer Australia to S.E.B., Cancer Council SA Beat Cancer Fund to T.P.H. and from the Australian Cancer Research Foundation to M.W.P. Funding from the Victorian Government Operational Infrastructure Support Scheme to St Vincent's Institute is acknowledged. S.E.B is a Postdoctoral Fellow supported by the Leukaemia Foundation. T.P.H. is an NHMRC Practitioner Fellow and M.W.P. is an NHMRC Research Fellow.