Journal article

Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: identification of sex-, disease- and treatment-regulated miRNAs

Bianca C Bernardo, Jenny YY Ooi, Aya Matsumoto, Yow Keat Tham, Saloni Singla, Helen Kiriazis, Natalie L Patterson, Junichi Sadoshima, Susanna Obad, Rubyc Y Lin, Julie R McMullen

JOURNAL OF PHYSIOLOGY-LONDON | WILEY | Published : 2016

Abstract

KEY POINTS: MicroRNA (miRNA)-based therapies are in development for numerous diseases, including heart disease. Currently, very limited basic information is available on the regulation of specific miRNAs in male and female hearts in settings of disease. The identification of sex-specific miRNA signatures has implications for translation into the clinic and suggests the need for customised therapy. In the present study, we found that a miRNA-based treatment inhibiting miRNA-34a (miR-34a) was more effective in females in a setting of moderate dilated cardiomyopathy than in males. Furthermore, the treatment showed little benefit for either sex in a setting of more severe dilated cardiomyopathy ..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Australian Research Council Future Fellowship


Funding Acknowledgements

This study was funded by National Health and Medical Research Council Project Grant 586603 (to JRM and RCYL), and was also supported in part by the Victorian Government's Operational Infrastructure Support Program. JRM is a National Health and Medical Research Council Senior Research Fellow (586604 & 1078985). JRM and RCYL were also supported by an Australian Research Council Future Fellowship (FT0001657) and a University of New South Wales Vice Chancellor Research Fellowship, respectively.