Journal article

Enhanced phosphoinositide 3-kinase(p110 alpha) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes

RH Ritchie, JE Love, K Huynh, BC Bernardo, DC Henstridge, H Kiriazis, YK Tham, G Sapra, C Qin, N Cemerlang, EJH Boey, K Jandeleit-Dahm, X-J Du, JR McMullen

DIABETOLOGIA | SPRINGER | Published : 2012

Abstract

AIMS/HYPOTHESIS: Diabetic cardiomyopathy is characterised by diastolic dysfunction, oxidative stress, fibrosis, apoptosis and pathological cardiomyocyte hypertrophy. Phosphoinositide 3-kinase (PI3K)(p110α) is a cardioprotective kinase, but its role in the diabetic heart is unknown. The aim of this study was to assess whether PI3K(p110α) plays a critical role in the induction of diabetic cardiomyopathy, and whether increasing PI3K(p110α) activity in the heart can prevent the development of cardiac dysfunction in a setting of diabetes. METHODS: Type 1 diabetes was induced with streptozotocin in adult male cardiac-specific transgenic mice with increased PI3K(p110α) activity (constitutively acti..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by National Heart Foundation Fellowship


Awarded by Australia Research Council


Funding Acknowledgements

This work was supported by a National Health and Medical Research Council (NHMRC) of Australia project grant (ID526638 to RHR, JRM and KJD), and supported in part by the Victoria Government's Operational Infrastructure Support Program. KH is supported by an Australian Postgraduate Award. DCH is supported by a National Heart Foundation Fellowship (PF 10M 5347). RHR, KJD, XJD and JRM are NHMRC Senior Research Fellows (IDs 472673, 526605, 317808 and 586604). JRM is supported by an Australia Research Council Future Fellowship (FT0001657).