Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise
Martin Whitham, Benjamin L Parker, Martin Friedrichsen, Janne R Hingst, Marit Hjorth, William E Hughes, Casey L Egan, Lena Cron, Kevin I Watt, Rhiannon P Kuchel, Navind Jayasooriah, Emma Estevez, Tim Petzold, Catherine M Suter, Paul Gregorevic, Bente Kiens, Erik A Richter, David E James, Jorgen FP Wojtaszewski, Mark A Febbraio
Cell Metabolism | CELL PRESS | Published : 2018
Awarded by Australian Research Council
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by Danish Research Council
Awarded by Novo Nordisk Foundation
The authors acknowledge Deb Ramsey and the team at Alfred Medical Research and Education Precinct Animal Services, Melbourne, Australia; Associate Professor Mark Molloy and staff of the Australian Proteomic Analysis Facility; and Dr. Martin Pal for assistance with the <SUP>13</SUP>C<INF>6</INF>-lysine mouse labeling. Furthermore, the authors would like to thank Prof. Tami Geiger and Dr. Michal Harel for advice on vesicle isolation and sample processing and Claire Vennin for assistance with the IVIS analysis, and also acknowledge the skilled assistance of Betina Bolmgren, Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. We would also like to thank staff at the Garvan Institute of Medical Research, Clinical Research Facility and volunteers for assistance in providing plasma samples for method optimization and all volunteers for participating in the exercise experiments. This research has been facilitated by access to the University of Sydney's Mass Spectrometry Core Facility. This project was supported by grants from the Australian Research Council (DP130103573) and National Health and Medical Research Council (NHMRC) (APP1062436) to M.A.F. and M.W. M.A.F., B.J.P., and D.E.J. are Fellows of the NHMRC. The study was also funded by The Danish Research Council (DFF 1333-00029B/DFF00725B for M.F. and DFF 0602-02277B for J.F.P.W.) and The Novo Nordisk Foundation (R195-A16471 for J.F.P.W.), and M.F. was the recipient of a fellowship from the Danish Diabetes Academy funded by the Novo Nordisk Foundation.