Journal article
Association of ß-Amyloid and apolipoprotein e e4 with memory decline in preclinical Alzheimer disease
YY Lim, P Kalinowski, RH Pietrzak, SM Laws, SC Burnham, D Ames, VL Villemagne, CJ Fowler, SR Rainey-Smith, RN Martins, CC Rowe, CL Masters, PT Maruff
JAMA Neurology | AMER MEDICAL ASSOC | Published : 2018
Abstract
IMPORTANCE Older age, high levels of ß-amyloid (Aß), and the presence of the apolipoprotein E (APOE) e4 allele are risk factors for Alzheimer disease (AD). However, the extent to which increasing age, Aß, and e4 are associated with memory decline remains unclear, and the age at which memory decline begins for Aß-positive e4 carriers and noncarriers has not been determined. OBJECTIVE To determine the association of age, Aß level, and APOE e4 with memory decline in a large group of cognitively healthy older adults. DESIGN, SETTING, AND PARTICIPANTS This longitudinal observational study included cognitively healthy older adults (age >60 years) enrolled in the Australian Imaging, Biomarkers and ..
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Funding Acknowledgements
This study was supported in part by the study partners Commonwealth Scientific Industrial and Research Organization (CSIRO), Edith Cowan University, Mental Health Research Institute, National Ageing Research Institute, Austin Health, and CogState, Ltd; the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program; the Science and Industry Endowment Fund (SIEF); the Cooperative Research Centre for Mental Health, an Australian government initiative; and the Dementia Research Development Fellowship from the NHMRC-Australian Research Council (Dr Lim).