Book Chapter

Engineering Niches for Skin and Wound Healing

MW Findlay, GC Gurtner

Biology and Engineering of Stem Cell Niches | Published : 2017


Optimization of wound healing has been a major goal of medical care throughout history. A myriad of devices, dressings, and therapies have been developed to control the local wound environment, facilitate timely healing, and modulate scar. Despite this, chronic wounds remain a major health burden, scarless wound healing is an aspirational goal, and hypertrophic and keloid scar formation are unpredictable and difficult to treat. Stem cells play a vital role in both wound healing and normal skin homeostasis, prompting their application to wounds and local tissues in efforts to optimize wound healing. However, significant barriers to their use remain, in the form of variable results, regulatory..

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