The regenerative role of adipose-derived stem cells (ADSC) in plastic and reconstructive surgery.
Naghmeh Naderi, Emman J Combellack, Michelle Griffin, Tina Sedaghati, Muhammad Javed, Michael W Findlay, Christopher G Wallace, Afshin Mosahebi, Peter Em Butler, Alexander M Seifalian, Iain S Whitaker
Int Wound J | Published : 2017
The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs offers a paradigm shift in plastic and reconstructive surgery. The use of either embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) in clinical situations is limited because of regulations and ethical considerations even though these cells are theoretically highly beneficial. Adult mesenchymal stem cells appear to be an ideal stem cell population for practical regenerative medicine. Among these cells, adipose-derived stem cells (ADSC) have the potential to differentiate the mesenchymal, ectodermal and endodermal lineages and are easy to harvest. Additionally, adipose ..View full abstract