Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi; I Vitale; SA Aaronson; JM Abrams; D Adam; P Agostinis; ES Alnemri; L Altucci; I Amelio; DW Andrews; M Annicchiarico-Petruzzelli; AV Antonov; E Arama; EH Baehrecke; NA Barlev; NG Bazan; F Bernassola; MJM Bertrand; K Bianchi; MV Blagosklonny; K Blomgren; C Borner; P Boya; C Brenner; M Campanella; E Candi; D Carmona-Gutierrez; F Cecconi; FKM Chan; NS Chandel; EH Cheng; JE Chipuk; JA Cidlowski; A Ciechanover; GM Cohen; M Conrad; JR Cubillos-Ruiz; PE Czabotar; V D'Angiolella; TM Dawson; VL Dawson; V De Laurenzi; R De Maria; KM Debatin; RJ Deberardinis; M Deshmukh; N Di Daniele; F Di Virgilio; VM Dixit; SJ Dixon; CS Duckett; BD Dynlacht; WS El-Deiry; JW Elrod; GM Fimia; S Fulda; AJ García-Sáez; AD Garg; C Garrido; E Gavathiotis; P Golstein; E Gottlieb; DR Green; LA Greene; H Gronemeyer; A Gross; G Hajnoczky; JM Hardwick; IS Harris; MO Hengartner; C Hetz; H Ichijo; M Jäättelä; B Joseph; PJ Jost; PP Juin; WJ Kaiser; M Karin; T Kaufmann; O Kepp; A Kimchi; RN Kitsis; DJ Klionsky; RA Knight; S Kumar; SW Lee; JJ Lemasters; B Levine; A Linkermann; SA Lipton; RA Lockshin; C López-Otín; SW Lowe; T Luedde; E Lugli; M MacFarlane; F Madeo; M Malewicz; W Malorni; G Manic

Journal article

Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi, I Vitale, SA Aaronson, JM Abrams, D Adam, P Agostinis, ES Alnemri, L Altucci, I Amelio, DW Andrews, M Annicchiarico-Petruzzelli, AV Antonov, E Arama, EH Baehrecke, NA Barlev, NG Bazan, F Bernassola, MJM Bertrand, K Bianchi, MV Blagosklonny Show all

Cell Death and Differentiation | NATURE PUBLISHING GROUP | Published : 2018

DOI: 10.1038/s41418-017-0012-4

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Abstract

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosi..

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University of Melbourne Researchers

Peter Czabotar Author

John Silke Author

Andreas Strasser Author

Grants

Awarded by Agence Nationale de la Recherche

Funding Acknowledgements

We are indebted with Dr. Avi Ashkenazi (Genentech Inc.) for his constructive suggestions. We apologize to the authors of several high-quality articles dealing with mechanistic or pathophysiological aspects of cell death that we were not able to properly discuss. L.G. is supported by an intramural startup from the Department of Radiation Oncology of Weill Cornell Medical College (New York, US), and by Sotio a.c. (Prague, Czech Republic). I.V. is supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC, IG 2017 grant number 20417), Ministero Italiano della Salute (grant number RF_GR-2011-02351355), Ministero Italiano dell'Istruzione, dell'Universita e della Ricerca (MIUR, Programma per i Giovani Ricercatori "Rita Levi Montalcini" 2010). G.K. is supported by the French Ligue contre le Cancer (equipe labellisee); Agence National de la Recherche (ANR)-Projets blancs; ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancer (ARC); Canceropole Ile-de-France; Institut National du Cancer (INCa); Institut Universitaire de France; Fondation pour la Recherche Medicale (FRM); the European Commission (ArtForce); the European Research Council (ERC); the LeDucq Foundation; the LabEx Immuno-Oncology; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); the SIRIC Cancer Research and Personalized Medicine (CARPEM); and the Paris Alliance of Cancer Research Institutes (PACRI).