Journal article

Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease.

MF Kagnoff, YJ Paterson, PJ Kumar, DD Kasarda, FR Carbone, DJ Unsworth, RK Austin

Gut | Published : 1987

Abstract

We previously noted a region of amino acid sequence homology between A-gliadin, a major alpha-gliadin component known to activate coeliac disease, and the early region E1b protein of human adenovirus serotype 12 (Ad12), an adenovirus isolated from the human intestinal tract. In the present study sera from coeliac disease patients from the United Kingdom and the United States were assayed for neutralising antibody to Ad12 as evidence of past exposure to that virus and for antibody to synthetic peptides of A-gliadin from the region of shared sequence with the Ad12 E1b protein. Eighty nine per cent of untreated coeliac disease patients had evidence of previous Ad12 infection. There was also a s..

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University of Melbourne Researchers