Drug-induced prolonged repolarisation (acquired long QT syndrome) arrhythmias

Abstract

Long QT Syndrome is a genetically determined disease of protein structures in the heart called ionic channels that control the flow of ions such as sodium, potassium and calcium, which produce the electrical activity of heart, depolarisation and repolarisation. Measurement of the QT interval on the electrocardiogram (ECG) can be quite difficult. Treatment of TdP due to ALQTS entails withdrawal of any precipitating agent, administration of MgSO4, and potassium supplements. Correction of bradycardia is very important and temporary pacing may be necessary. If an antiarrhythmic agent is required after all the above, then lignocaine can be used.