Journal article
Shuffling peptides to create T-cell epitopes: Does the immune system play cards
SI Mannering, M So, CM Elso, TWH Kay
Immunology and Cell Biology | NATURE PUBLISHING GROUP | Published : 2018
DOI: 10.1111/imcb.1015
Abstract
For a long time, immunologists have believed that classical CD4+ and CD8+ T cells recognize peptides (referred to as epitopes), derived from protein antigens presented by MHC/HLA class I or II. Over the past 10-15 years, it has become clear that epitopes recognized by CD8+, and more recently CD4+ T cells, can be formed by protein splicing. Here, we review the discovery of spliced epitopes recognized by tumor-specific human CD8+ T cells. We discuss how these epitopes are formed and some of the unusual variants that have been reported. Now, over a decade since the first report, evidence is emerging that spliced CD8+ T-cell epitopes are much more common, and potentially much more important, tha..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
SIM was supported by grants from: The Juvenile Diabetes Research Foundation (JDRF 17-2011-527), The Australian National Health and Medical Research Council (NHMRC GNT1123586), Diabetes Australia Research Trust Millennium Award T1D (Y17M1-MANS) and JDRF-Australia Clinical Research Network, Innovation Award. MS was supported by an NHMRC Postgraduate Scholarship (APP1094337) and a JDRF-Australia PhD Top-up Scholarship. TK is supported by an NHMRC Program Grant (APP1037321) and JDRF/Department of Health and Aging grants. All authors acknowledge the support from the Operational Infrastructure Support Program of the Victorian Government.