The effects of changes in loading conditions and modulation of inotropic state on the myocardial performance index: Comparison with conductance catheter measurements

Abstract

The myocardial performance index (MPI), or Tei index, has been shown to be useful in the assessment of global myocardial performance. There are few invasive data however, which examine its load dependence or sensitivity to acute changes in contractile function. The purpose of this study was therefore to study formally the effect of clinically relevant changes in these parameters in an animal model. We examined 10 Yorkshire pigs using echocardiographic assessment and simultaneous measurements of intraventricular pressure and volume by conductance catheterization. With dobutamine infusion, there was no significant change in the MPI (0.26 ± 0.13-0.22 ± 0.11; p = 0.42), but dP/dtmaxincreased sig..