Journal article

Effects of vitamin D supplementation on inflammatory markers in heart failure: a systematic review and meta-analysis of randomized controlled trials

Alexander J Rodriguez, Aya Mousa, Peter R Ebeling, David Scott, Barbora de Courten

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2018

Abstract

Vitamin D is reported to have anti-inflammatory properties; however the effects of vitamin D supplementation on inflammation in patients with heart failure (HF) have not been established. We performed a systematic review and meta-analysis examining effects of vitamin D supplementation on inflammatory markers in patients with HF. MEDLINE, CINAHL, EMBASE, All EBM, and Clinical Trials registries were systematically searched for RCTs from inception to 25 January 2017. Two independent reviewers screened all full text articles (no date or language limits) for RCTs reporting effects of vitamin D supplementation (any form, route, duration, and co-supplementation) compared with placebo or usual care ..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council R.D. Wright Biomedical Career Development Fellowship


Awarded by National Heart Foundation Future Leader Fellowship


Funding Acknowledgements

AJR & AM are recipients of Australian Postgraduate Award Scholarships from Monash University. DS is supported by a National Health and Medical Research Council R.D. Wright Biomedical Career Development Fellowship (GNT1123014). BdC is supported by a National Heart Foundation Future Leader Fellowship (100864). We wish to thank the authors of the included articles for sending the required data for meta-analysis.