Journal article
High baseline levels of tumor necrosis factor receptor 1 are associated with progression of kidney disease in indigenous australians with diabetes: The eGFR follow-up study
ELM Barr, F Barzi, JT Hughes, G Jerums, WE Hoy, K O'Dea, GRD Jones, PD Lawton, ADH Brown, M Thomas, EI Ekinci, A Sinha, A Cass, RJ MacIsaac, LJ Maple-Brown
Diabetes Care | AMER DIABETES ASSOC | Published : 2018
DOI: 10.2337/dc17-1919
Abstract
OBJECTIVE To examine the association between soluble tumor necrosis factor receptor 1 (sTNFR1) levels and kidney disease progression in Indigenous Australians at high risk of kidney disease. RESEARCH DESIGN AND METHODS This longitudinal observational study examined participants aged ≥18 years recruited from >20 sites across diabetes and/or kidney function strata. Baseline measures included sTNFR1, serum creatinine, urine albumin-to-creatinine ratio (uACR), HbA1c, C-reactive protein (CRP), waist-to-hip ratio, systolic blood pressure, and medical history. Linear regression was used to estimate annual change in estimated glomerular filtration rate (eGFR) for increasing sTNFR1, and Cox proportio..
View full abstractGrants
Awarded by Diabetes Australia Research Trust
Funding Acknowledgements
The eGFR Study was funded by the National Health and Medical Research Council (NHMRC; project grants 545202 and 1021460), with additional support from SVHA Inclusive Health Innovation Fund, Kidney Health Australia, NHMRC (program grant 631947), the Colonial Foundation, Diabetes Australia Research Trust, Rebecca L. Cooper Foundation, and SeaSwift Thursday Island. E.L.M.B. was supported by an NHMRC Training Research Fellowship (APP1016612) and a National Heart Foundation of Australia post-doctoral fellowship (1012914). F.B. was supported by an NHMRC program grant (631947). J.T.H. was supported by an NHMRC fellowship (1092576) and Royal Australasian College of Physicians Jacquot Research Establishment Award. W.E.H. directs the NHMRC-funded Centre for Research Excellence in Chronic Kidney Disease (1079502). P.D.L. was supported by an NHMRC scholarship (1038721), a Royal Australasian College of Physicians Jacquot Research Establishment Award, and an NHMRC Early Career Fellowship (1120640). A.D.H.B. was supported by a Viertel Senior Medical Research Fellowship from the Sylvia and Charles Viertel Charitable Foundation. E.I.E. was supported by an NHMRC Early Career Fellowship (the Health Professional Research Fellowship, part time, 1054312), a Viertel Clinical Investigatorship, the Royal Australasian College of Physicians JDRF Research Establishment Fellowship, and project funding from the Sir Edward "Weary" Dunlop Medical Research Foundation. R.J.M. was supported by an Australian Diabetes Society-Servier Diabetes Research Fellowship and the Rebecca L. Cooper Foundation. L.J.M.-B. was supported by an NHMRC fellowship (605837) and an NHMRC practitioner fellowship (1078477).The views expressed in this publication are those of the authors and do not reflect the views of the NHMRC. The funding bodies had no role in the study design; in the collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication.