Journal article
Trajectories of eGFR decline over a four year period in an Indigenous Australian population at high risk of CKD-the eGFR follow up study
F Barzi, GRD Jones, JT Hughes, PD Lawton, W Hoy, K O'Dea, G Jerums, RJ MacIsaac, A Cass, LJ Maple-Brown
Clinical Biochemistry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018
Abstract
Being able to estimate kidney decline accurately is particularly important in Indigenous Australians, a population at increased risk of developing chronic kidney disease and end stage kidney disease. The aim of this analysis was to explore the trend of decline in estimated glomerular filtration rate (eGFR) over a four year period using multiple local creatinine measures, compared with estimates derived using centrally-measured enzymatic creatinine and with estimates derived using only two local measures. Method: The eGFR study comprised a cohort of over 600 Aboriginal Australian participants recruited from over twenty sites in urban, regional and remote Australia across five strata of health..
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Awarded by Diabetes Australia Research Trust
Funding Acknowledgements
The authors gratefully acknowledge the support of the eGFR Q13 study participants, study staff and partner organizations. We thank Dr. Kevin Warr and Dr. William Majoni for facilitating participant recruitment and follow-up at the sites of their employing organization and Loyla Leysley, Sian Graham, Mary Ward and Joseph Fitz for assistance with follow-up in their communities. The authors also thank Melbourne Pathology for providing the technical support in the enzymatic creatinine analysis and Roche Diagnostics for supplying the enzymatic creatinine reagent kit for the baseline study. The eGFR study was funded by the National Health and Medical Research Council of Australia (NHMRC, Project Grants no. 545202 and no. 1021460), with additional support from Kidney Health Australia, NHMRC Program Grant (no. 631947), the Colonial Foundation, Diabetes Australia Research Trust, Rebecca L Cooper Foundation and SeaSwift, Thursday Island. ELMB was supported by an NHMRC Training Research Fellowship (APP1016612); LJM-B was supported by an NHMRC Fellowship (no. 605837) and NHMRC Practitioner Fellowship (no. 1078477); FB was supported by NHMRC Program Grant (no. 631947); JTH was supported by NHMRC Fellowship no. 1092576 and RACP Jacquot Research Establishment Award; PDL was supported by NHMRC Scholarship no. 1038721 and RACP Jacquot Research Establishment Award; EIE was supported by an NHMRC Early Career Fellowship: Health Professional Research Fellowship (Part Time, no. 1054312), Viertel Clinical Investigatorship and a RACP JDRF Research Establishment Fellowship. WH directs the NHMRC funded Centre for Research Excellence in Chronic Kidney Disease (no. 1079502). ADHB is supported by a Viertel Senior Medical Research Fellowship. RM was supported by an Australian Diabetes Society-Servier Diabetes Research Grant, Rebecca Cooper Medical Research Foundation and the St. Vincent's Hospital Melbourne Research Endowment Fund. The views expressed in this publication are those of the authors and do not reflect the views of the NHMRC. Funding bodies had no role in the study design, in the collection, analysis or interpretation of data, in the writing of the manuscript or the decision to submit the manuscript for publication.