Journal article
Associations of dietary protein and fiber intake with brain and blood amyloid-β
WMADB Fernando, SR Rainey-Smith, SL Gardener, VL Villemagne, SC Burnham, SL Macaulay, BM Brown, VB Gupta, HR Sohrabi, M Weinborn, K Taddei, SM Laws, K Goozee, D Ames, C Fowler, P Maruff, CL Masters, O Salvado, CC Rowe, RN Martins
Journal of Alzheimer S Disease | IOS PRESS | Published : 2018
DOI: 10.3233/JAD-170742
Abstract
Accumulating evidence suggests a diet high in protein and fiber may confer some protection against Alzheimer's disease (AD). However, no human studies to-date have assessed the relationship between protein and fiber intake, and plasma and brain amyloid-β (Aβ). Consequently, this cross-sectional study, investigated the association of self-reported dietary intakes of protein and fiber, with plasma and brain Aβ burden (n = 541, and n = 162 respectively), in a well-characterized cohort of cognitively normal older adults, drawn from the larger Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. We observed 12.59 and 8.43 higher odds of 'high' brain Aβ burden (PiB PET SUVR≥1.5) if ..
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Funding Acknowledgements
Funding for the study was provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF) in partnership with Edith Cowan University (ECU), The Florey Institute of Neuroscience and Mental Health, Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, CogState Ltd., Hollywood Private Hospital, and Sir Charles Gairdner Hospital. The study also received funding from the National Health and Medical Research Council (NHMRC), the Dementia Collaborative Research Centres program (DCRC2), the Cooperative Research Centre (CRC) for Mental Health - funded through the CRC Program (an Australian Government Initiative, Grant ID: 20100104), and the McCusker Alzheimer's Research Foundation, and Operational Infrastructure Support from the Government of Victoria.