Journal article
Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific
A Waltmann, C Koepfli, N Tessier, S Karl, A Fola, AW Darcy, L Wini, GLA Harrison, C Barnadas, C Jennison, H Karunajeewa, S Boyd, M Whittaker, J Kazura, M Bahlo, I Mueller, AE Barry
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2018
Abstract
The human malaria parasite Plasmodium vivax is more resistant to malaria control strategies than Plasmodium falciparum, and maintains high genetic diversity even when transmission is low. To investigate whether declining P. vivax transmission leads to increasing population structure that would facilitate elimination, we genotyped samples from across the Southwest Pacific region, which experiences an eastward decline in malaria transmission, as well as samples from two time points at one site (Tetere, Solomon Islands) during intensified malaria control. Analysis of 887 P. vivax microsatellite haplotypes from hyperendemic Papua New Guinea (PNG, n = 443), meso-hyperendemic Solomon Islands (n = ..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This study was supported by a National Institutes of Health (NIH, http://www.nih.gov) International Centers of Excellence in Malaria Research Grant U19AI089686 awarded to JK, National Health and Medical Research Council of Australia (NHMRC, http://www.nhmrc.gov.au) Project Grants 1021544 (IM) and 1003825 (AEB), NHMRC Senior Research Fellowship 1043345 (IM) and NHMRC Postgraduate Scholarship 1056511 (AW). The authors are grateful for support from the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.