Journal article

Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26

SA Treloar, J Wicks, DR Nyholt, GW Montgomery, M Bahlo, V Smith, G Dawson, IJ Mackay, DE Weeks, ST Bennett, A Carey, KR Ewen-White, DL Duffy, DT O'Connor, DH Barlow, NG Martin, SH Kennedy

The American Journal of Human Genetics | UNIV CHICAGO PRESS | Published : 2005

Abstract

Endometriosis is a common gynecological disease that affects up to 10% of women in their reproductive years. It causes pelvic pain, severe dysmenorrhea, and subfertility. The disease is defined as the presence of tissue resembling endometrium in sites outside the uterus. Its cause remains uncertain despite >50 years of hypothesis-driven research, and thus the therapeutic options are limited. Disease predisposition is inherited as a complex genetic trait, which provides an alternative route to understanding the disease. We seek to identify susceptibility loci, using a positional-cloning approach that starts with linkage analysis to identify genomic regions likely to harbor these genes. We con..

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University of Melbourne Researchers