Journal article

Telomere length is reduced in 9-to 16-year-old girls exposed to gestational diabetes in utero

Line Hjort, Regan Vryer, Louise G Grunnet, David Burgner, Sjurdur F Olsen, Richard Saffery, Allan Vaag

Diabetologia | SPRINGER | Published : 2018

Abstract

AIMS/HYPOTHESIS: Shortened telomere length is a marker of cell damage and is associated with oxidative stress, chronic inflammation and metabolic disease. We hypothesised that the offspring of women with gestational diabetes mellitus (GDM) with increased risk of cardiovascular and metabolic diseases might exhibit shorter telomere length. METHODS: We investigated telomere length in 439 GDM and 469 control group offspring, aged between 9 and 16 years, recruited from the Danish National Birth Cohort. Relative telomere length was measured in peripheral blood DNA (n = 908) using a quantitative PCR approach. Multivariate regression analysis was used to investigate the association between mothers' ..

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Grants

Awarded by Innovation Fund Denmark


Awarded by Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health


Awarded by European Commission


Funding Acknowledgements

This study was funded by the Danish Council for Strategic Research, the Innovation Fund Denmark (09-067124 and 11-115923), the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (contract #HHSN275201000020C), The European Commission (FP7-289346-EarlyNutrition), Rigshospitalet/The Copenhagen University Hospital, the faculty of Health and Medical Sciences, Copenhagen University and the Danish Diabetes Academy supported by the Novo Nordisk Foundation.