Telomere length is reduced in 9-to 16-year-old girls exposed to gestational diabetes in utero
Line Hjort, Regan Vryer, Louise G Grunnet, David Burgner, Sjurdur F Olsen, Richard Saffery, Allan Vaag
Diabetologia | SPRINGER | Published : 2018
AIMS/HYPOTHESIS: Shortened telomere length is a marker of cell damage and is associated with oxidative stress, chronic inflammation and metabolic disease. We hypothesised that the offspring of women with gestational diabetes mellitus (GDM) with increased risk of cardiovascular and metabolic diseases might exhibit shorter telomere length. METHODS: We investigated telomere length in 439 GDM and 469 control group offspring, aged between 9 and 16 years, recruited from the Danish National Birth Cohort. Relative telomere length was measured in peripheral blood DNA (n = 908) using a quantitative PCR approach. Multivariate regression analysis was used to investigate the association between mothers' ..View full abstract
Awarded by Innovation Fund Denmark
Awarded by Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Awarded by European Commission
This study was funded by the Danish Council for Strategic Research, the Innovation Fund Denmark (09-067124 and 11-115923), the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (contract #HHSN275201000020C), The European Commission (FP7-289346-EarlyNutrition), Rigshospitalet/The Copenhagen University Hospital, the faculty of Health and Medical Sciences, Copenhagen University and the Danish Diabetes Academy supported by the Novo Nordisk Foundation.