Journal article
Controlled formation and binding selectivity of discrete oligo(methyl methacrylate) Stereocomplexes
JM Ren, J Lawrence, AS Knight, A Abdilla, RB Zerdan, AE Levi, B Oschmann, WR Gutekunst, SH Lee, Y Li, AJ McGrath, CM Bates, GG Qiao, CJ Hawker
Journal of the American Chemical Society | AMER CHEMICAL SOC | Published : 2018
DOI: 10.1021/jacs.7b13095
Abstract
The triple-helix stereocomplex of poly(methyl methacrylate) (PMMA) is a unique example of a multistranded synthetic helix that has significant utility and promise in materials science and nanotechnology. To gain a fundamental understanding of the underlying assembly process, discrete stereoregular oligomer libraries were prepared by combining stereospecific polymerization techniques with automated flash chromatography purification. Stereocomplex assembly of these discrete building blocks enabled the identification of (1) the minimum degree of polymerization required for the stereocomplex formation and (2) the dependence of the helix crystallization mode on the length of assembling precursors..
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Awarded by National Institutes of Health
Funding Acknowledgements
The research reported here was supported by the NSF MRSEC Program through DMR 1720256. These studies made use of shared facilities of the UCSB MRSEC (NSF DMR 1720256), a member of the Materials Research Facilities Network (www.mrfn.org). Additional support was provided by the Institute for Collaborative Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research Office. The content of the information does not necessarily reflect the position or the policy of the government, and no official endorsement should be inferred. J.M.R thanks the Victorian Endowment for Science, Knowledge and Innovation (VESKI) for a postdoctoral fellowship. A.S.K. was supported by a postdoctoral fellowship from the Arnold and Mabel Beckman Foundation. B.O. acknowledges the Alexander von Humboldt-Foundation for a Feodor Lynen Research Fellowship. W.R.G. thanks the NIH for a postdoctoral fellowship (F32GM108323).