Differential expression profiles of conserved Snail transcription factors in the mouse testis
DJ Micati, GR Hime, EA McLaughlin, HE Abud, KL Loveland
ANDROLOGY | WILEY | Published : 2018
Snail transcription factors are key regulators of cellular transitions during embryonic development and tumorigenesis. The closely related SNAI1 and SNAI2 proteins induce epithelial-mesenchymal transitions (EMTs), acting predominantly as transcriptional repressors, while the functions of SNAI3 are unknown. An initial examination of Snai2-deficient mice provided evidence of deficient spermatogenesis. To address the hypothesis that Snail proteins are important for male fertility, this study provides the first comprehensive cellular expression profiles of all three mammalian Snail genes in the post-natal mouse testis. To evaluate Snail transcript expression profiles, droplet digital (dd) PCR an..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Work was supported by grants from the National Health and Medical Research Council of Australia (Project grant ID1048110 to GH, HA, KL and Fellowship ID1079646 to KL).