Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis)

J Goldenberg; V Cipriani; TNW Jackson; K Arbuckle; J Debono; D Dashevsky; N Panagides; MP Ikonomopoulou; I Koludarov; B Li; RC Santana; A Nouwens; A Jones; C Hay; N Dunstan; L Allen; B Bush; JJ Miles; L Ge; HF Kwok; BG Fry

Journal article

Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis)

J Goldenberg, V Cipriani, TNW Jackson, K Arbuckle, J Debono, D Dashevsky, N Panagides, MP Ikonomopoulou, I Koludarov, B Li, RC Santana, A Nouwens, A Jones, C Hay, N Dunstan, L Allen, B Bush, JJ Miles, L Ge, HF Kwok Show all

Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology | ELSEVIER SCIENCE INC | Published : 2018

DOI: 10.1016/j.cbpc.2018.01.001

Abstract

Pseudechis (black snakes) is an Australasian elapid snake genus that inhabits much of mainland Australia, with two representatives confined to Papua New Guinea. The present study is the first to analyse the venom of all 9 described Pseudechis species (plus one undescribed species) to investigate the evolution of venom composition and functional activity. Proteomic results demonstrated that the typical Pseudechis venom profile is dominated by phospholipase A2 toxins. Strong cytotoxicity was the dominant function for most species. P. porphyriacus, the most basal member of the genus, also exhibited the most divergent venom composition, being the only species with appreciable amounts of procoagu..

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University of Melbourne Researchers

Timothy Jackson Author

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

HFK was supported by the Science and Technology Development Fund of Macau SAR (FDCT) (019/2017/A1). BL was receipt a studentship from the University of Macau Faculty of Health Sciences and Multi-Year Research Grant (MYRG2015-00025-FHS). JJM is supported by a NHMRC Research Fellowship (1131732). MPI is a "Marie Curie" AMAROUT Fellow.