Journal article

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function

Srinivasan Sundararaj, Jingjing Zhang, S Harsha Krovi, Romain Bedel, Kathryn D Tuttle, Natacha Veerapen, Gurdyal S Besra, Yogesh Khandokar, T Praveenaa, Jerome Le Nours, Jennifer L Matsuda, Jamie Rossjohn, Laurent Gapin

Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2018

Grants

Awarded by NIH


Awarded by Cancer Center Support Grant


Awarded by Worldwide Cancer Research Grant


Awarded by Australian Research Council


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

We thank members of our laboratories for thoughtful discussions and critical comments on the manuscript; Chyung-Ru Wang for the CD1D1D2<SUP>-/-</SUP> mice used in this study; Paul B. Savage and Luc Teyton for the alpha- and ss-psychosine antigens; the National Jewish Health flow cytometry facility, the Mucosal and Vaccine Research Colorado Flow Core, and the University of Colorado flow cytometry shared resource facility for assistance with cell sorting; the Center for Genes, Environment, and Health at National Jewish Health for sequencing; the National Institutes of Health (NIH) core facility for CD1d tetramers; the staff at the Australian Synchrotron for assistance with data collection; and the staff at the Monash Macromolecular crystallization facility. This work was supported by NIH Grants AI121761 and AI124076 (to L.G.); an American Association for Immunologists Careers in Immunology Fellowship (L.G.); Cancer Center Support Grant P30CA046934; the National Health and Medical Research Council; Worldwide Cancer Research Grant 16-1106 (to J.R.); and an Australian Research Council Future Fellowship FT160100074 (to J.L.N.).