Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response
Kaur Alasoo, Julia Rodrigues, Subhankar Mukhopadhyay, Andrew J Knights, Alice L Mann, Kousik Kundu, Christine Hale, Gordon Dougan, Daniel J Gaffney
Nature Genetics | NATURE RESEARCH | Published : 2018
Awarded by Wellcome Trust
Awarded by Estonian Research Council
Awarded by Medical Research Council
We thank L. Parts, J. Schwartzentruber, C. Wallace, L. Milani, K. Lepik and H. Peterson for helpful comments on the manuscript. We thank R. Nelson for assistance and early access to HipSci iPSC lines. We thank R. Kreuzhuber for providing access to the imputed genotype data from the Fairfax study. We thank C.D. Brown for helpful comments on the manuscript. We also thank WTSI DNA Pipelines and Cytometry Core Facility for their sequencing and flow cytometry services. This work was supported by Wellcome Trust grant WT098051 (G.D. and D.J.G.). K. A. was supported by a PhD fellowship from the Wellcome Trust (WT099754/Z/12/Z) and a postdoctoral fellowship from the Estonian Research Council (MOBJD67). The iPSC lines were generated at the Wellcome Trust Sanger Institute, under the Human Induced Pluripotent Stem Cell Initiative funded by a strategic award (WT098503) from the Wellcome Trust and Medical Research Council. We also acknowledge Life Science Technologies Corporation as the provider of cytotune.