Journal article

Comparison of high-dose and standard-dose pancreatic enzyme capsules in children with cystic fibrosis

PJ Robinson

Australian Journal of Hospital Pharmacy | Published : 1998


Objective: To compare the efficacy of a high-dose, pancreatic enzyme supplement Creon Forte to that of a standard pancreatic enzyme supplement Cotazym S Forte in a group of children with cystic fibrosis. Methodology: 18 children with cystic fibrosis were enrolled in a 4-week open-labelled, randomised, two-period, crossover study in which equal doses of lipase were provided by either Creon Forte or Cotazym S Forte. Efficacy was determined by a 4-day faecal fat study at the end of each 2-week period. Patients were also asked to record daily the degree of abdominal symptoms including abdominal pain, abdominal bloating, diarrhoea, constipation, nausea, vomiting and anorexia. Results: No signific..

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