Journal article

Effect of clenbuterol on tracheal mucociliary transport in horses undergoing simulated long-distance transportation.

JL Norton, K Jackson, JW Chen, R Boston, RD Nolen-Walston

J Vet Intern Med | Published : 2013

Abstract

BACKGROUND: Pneumonia is observed in horses after long-distance transportation in association with confinement of head position leading to reduction in tracheal mucociliary clearance rate (TMCR). HYPOTHESIS/OBJECTIVES: Clenbuterol, a beta-2 agonist shown to increase TMCR in the horse, will ameliorate the effects of a fixed elevated head position on large airway contamination and inflammation in a model of long-distance transportation model. ANIMALS: Six adult horses. METHODS: A cross-over designed prospective study. Horses were maintained with a fixed elevated head position for 48 hours to simulate long-distance transport, and treated with clenbuterol (0.8 μg/kg PO q12h) or a placebo startin..

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University of Melbourne Researchers