Exogenous L-lactate clearance in adult horses.
Pedro De Pedro, Pamela A Wilkins, Maureen A McMichael, Levent Dirikolu, Kara M Lascola, Stuart C Clark-Price, Raymond C Boston
J Vet Emerg Crit Care (San Antonio) | Published : 2012
OBJECTIVE: To determine endogenous production of L-lactate and the clearance of exogenous sodium L-lactate (ExLC) in healthy adult horses. DESIGN: A sodium L-lactate solution (1 mmol/kg body weight qs to 500 mL final volume in 0.9% NaCl) was adminstered IV over 15 minutes. Blood samples for L-lactate concentration [LAC] measurement were collected immediately prior to infusion, at 5, 10, and 15 minutes during infusion and at 1 minute intervals for 15 minutes, at 30, 45, 60, 120, and 180 minutes postinfusion. Disposition modeling and pharmacokinetic analysis was performed using proprietary software. SETTING: University Teaching Hospital. ANIMALS: Six clinically healthy adult horses. MEASUREMEN..View full abstract